É possível observar a forma irregular e o aumento do tamanho das papilas dérmicas, perda na definição do contorno, epiderme mais pigmentada (espaço entre as papilas), pois há maior quantidade de melanina e concentração irregular de melanina quando comparada à região perilesional (Escala 500 x500 µm). É possível observar papilas dérmicas regulares (redondas) com bordas bem definidas e esbranquiçadas e um espaço totalmente escuro entre elas, representando uma pigmentação regular (Escala 500 x500 µm) (B) Junção dermoepidérmica da região lesional.
It is possible to observe the irregular shape and increased size of dermal papillas, loss in their contour definition, more pigmented epidermis (space between the papillas) due to the higher amount and irregular concentration of melamin when compared to perilesional region (Scale 500 x500 µm)/ (A) Junção dermoepidérmica da região perilesional.
It is possible to observe regular shapped (round) dermal-pappilas with well-defined and whitish borders and an totally dark space between them representing an regular pigmentation (Scale 500 x500 µm) (B) Dermal-epidermal junction of lesional region. Figura 3 -(A) Dermal-epidermal junction of perilesional region. Finally, the study describes the characteristics of PIH and can help dermatologists toĭiagnose PIH with an innovative method that reduces the stress associated with a histological biopsy. Melanophages were observed in the papillary dermis, as well as changes in the size and shape of dermal papillae. The results showed an increase of epidermal pigmentation, a reduction of DEJ thickness, and no change in epidermal thickness. The brightness of the basal cell layer, the dermal-epidermal junction (DEJ) thickness, and the depth of dermal papillae were quantified and the morphological and structural features of the DEJ were analyzed. Thus, 12 subjects with previously diagnosed acne and PIH were selected for the study. The aim of this study was to characterize PIH and correlate the main aspects observed by RCM with the macroscopic characteristics of acne-related PIH. However, Reflectance Confocal Microscopy (RCM) has the potential to replace these methods since it is a noninvasive advanced technique and has a higher diagnostic accuracy than dermatoscopy.
Histological and clinical exams have been used for the diagnosis of PIH and to determine the correct treatment. Retinol activates the stem cells and gets them to essentially start producing more daughter cells a little bit faster, so that you can accelerate the production of new skin.Īutophagy is all about being able to recycle cellular components without damaging the cell, and it's a critical part of healthy aging in a cell or in an organism like us.Post-Inflammatory Hyperpigmentation (PIH) is a common pigmentary disorder in patients with pigmented skin.
#Texto contraste del acne free
Peptides are good at temporarily masking the appearance of fine lines, and to a lesser extent, wrinkles.Īntioxidants like Vitamin C are able to neutralize free radicals so they can no longer have detrimental effects on either the DNA or other biochemical components in the cell.
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UV damage is the #1 cause of "inflammaging." UV coming from the sun causes DNA damage in our stem cells and is a dramatic driver of chronic inflammation in the skin. "Inflammaging" is a fancy term for how chronic inflammation accelerates the aging process. Retinol: when can you expect results? Īutophagy is a critical part of healthy aging How long does it take for a skincare routine to show results?
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UV is the #1 cause of skin inflammaging Ĭhoices that are not great for your skin Also, he's going to talk about the chemistry behind some of the most popular skincare ingredients like retinol, peptides, and vitamin C, to explain how they work in the skin and make complicated biological processes like epigenetic, stem cell regeneration, and autophagy.īeauty Uncovered is brought to you by Olaplex, which invites you to go beyond the surface with the only system that rebuilds broken hair bonds. He will also talk about some of the most common skin conditions like acne, rosacea, and eczema, how they all have an inflammatory component, and the best ways to treat them. He will discuss how chronic everyday inflammation ages the skin and ways to reverse the process. He is a stem cell biologist and also the co-founder of Heraux. You are going to get the masterclass that you never knew you needed. Biotech Beauty: Anti-Inflammaging Skincareīiotech Beauty: Anti-Inflammaging Skincare | Ben Van Handel
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